- OLIG1, along with the OLIG2, regulates key stages of early oligodendrocyte development.
- Myelinating oligodendrocytes fulfill diverse functional roles, such as ensheathment of neurons to facilitate electrical conductivity, maintenance of axonal integrity and participation in signaling networks with neurons.
- OLIG1 function is critical for regulation of oligodendrogenesis during embryonic and fetal stages of CNS development, and it continues to be expressed in mature oligodendrocytes (Ligon et al. 2006).
- Elevated OLIG1 expression has also been found in certain brain tumors, particularly oligodendrogliomas (Hoang-Xuan et al. 2002).
|Promoter Constructs||ESC Lines||Mice|
|pEMS1172||mEMS1608, mEMS1609, mEMS1614, mEMS1615||mice generated using ESC mESM1615|
Figures A and B illustrate the expression pattern throughout cortical (CTX) and subcortical (SC) regions following anti-GFP immunocytochemistry. Within the cortex, individual cell bodies are distinctly labelled and “puffy” processes surround these cells. The EGFP expression does not appear to be enriched in white matter tracts or in the corpus callosum.